I agree that the 100+-acre farm is awkward at best. I'm unable to verify the exact acreage during the time period discussed on the marker. I thought using the + sign would be more readable from a distance, but I have found a reference to 100-plus (hyphen, plus written out) so I'm leaning toward that.
I also thought of changing the wording as you suggested.
The text of the marker in part: A thriving family-run business operated on this site from 1888 to 1913. John S. Burbank and his wife, Clara, started distributing ketchup to customers on John’s milk route and eventually sold product throughout New England. In a single year 12,000 bottles could be made from the 10,000 tomato plants grown on the farm’s 100-plus acres. Piccalilli, mustard, and applesauce were also produced.
What do you think of that change--"grown on the farm's 100-plus acres"?
Piccalilli, mustard, and applesauce were also produced.
Lynn Truss calls this comma 'an Oxford comma". This site leans away from that. In my view, the last item in a list should only be afforded a comma if it helps to eliminate ambiguity.